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Article

Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs.

Stem cell reports - 8 May 2018

Chang Chan-Jung, Kotini Andriana G, Olszewska Malgorzata, Georgomanoli Maria, Teruya-Feldstein Julie, Sperber Henrik, Sanchez Roberto, DeVita Robert, Martins Timothy J, Abdel-Wahab Omar, Bradley Robert K, Papapetrou Eirini P

Abstract excerpt

Connecting specific cancer genotypes with phenotypes and drug responses constitutes the central premise of precision oncology but is hindered by the genetic complexity and heterogeneity of primary cancer cells. Here, we use patient-derived induced pluripotent stem cells (iPSCs) and CRISPR/Cas9 genome editing to dissect the individual contributions of two recurrent genetic lesions, the splicing factor SRSF2 P95L...

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Source

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Identifiers

PMID: 29681544
DOI: 10.1016/j.stemcr.2018.03.020
PMCID: PMC5995368

Genes

SRSF2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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