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Article

Molecular progression to cervical precancer, epigenetic switch or sequential model?

21 Apr 2018

Abstract excerpt

The evolution of precancerous cervical lesions is poorly understood. A widely held model of cervical intraepithelial neoplasia grade 3 (CIN3) development is sequential progression from normal through CIN1 and CIN2 to CIN3. Another hypothesis, the "molecular switch" model, postulates that CIN3 can evolve directly from human papillomavirus (HPV)-infected normal epithelium without progressing through CIN1 and CIN2....

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PMID: 29679470
DOI: 10.1002/ijc.31549

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