Article
The majority of metachronous CIN1 and CIN3 lesions are caused by different human papillomavirus genotypes, indicating that the presence of CIN1 seems not to determine the risk for subsequent detection of CIN3.
Human pathology - 1 Feb 2014
Litjens Rogier J N T M, Van de Vijver Koen K, Hopman Anton H N, Ummelen Monique I, Speel Ernst-Jan M, Sastrowijoto Suprapto H, Van Gorp Toon, Slangen Brigitte F M, Kruitwagen Roy F P M, Krüse Arnold-Jan
Abstract excerpt
Cervical intraepithelial neoplasia (CIN) is historically viewed as a progressive biologic continuum leading to cervical cancer. However, it has been questioned whether CIN1 lesions ever progress. To this end, we evaluated the number of patients with a CIN3 and a previous CIN1 diagnosis. Subsequently, metachronous CIN1 and CIN3 lesions were reviewed and human papillomavirus (HPV) genotyping was performed to...
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