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Article

Phenotypic change and accumulation of smooth muscle cells in strictures in Crohn's disease: relevance to local angiotensin II system.

Journal of gastroenterology - 1 Aug 2010

Suekane Takehisa, Ikura Yoshihiro, Watanabe Kenji, Arimoto Junko, Iwasa Yoko, Sugama Yoshimi, Kayo Soichiro, Sugioka Kenichi, Naruko Takahiko, Maeda Kiyoshi, Hirakawa Kosei, Arakawa Tetsuo, Ueda Makiko

Abstract excerpt

BACKGROUND: Intestinal stricture lesions in Crohn's disease are characterized as submucosal fibromuscular accumulation. There has been a controversy about whether the fibrogenic cells in stricture lesions in Crohn's disease originate from a smooth muscle cell or a fibroblast lineage. In the present study, we aimed to elucidate: (1) the origin of the fibrogenic cells in stricture lesions; and (2) the roles of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20361214
DOI: 10.1007/s00535-010-0232-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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