Article
Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M.
Nature communications - 18 Apr 2018
Sampath Srinath C, Sampath Srihari C, Ho Andrew T V, Corbel Stéphane Y, Millstone Joshua D, Lamb John, Walker John, Kinzel Bernd, Schmedt Christian, Blau Helen M
Abstract excerpt
The balance between stem cell quiescence and proliferation in skeletal muscle is tightly controlled, but perturbed in a variety of disease states. Despite progress in identifying activators of stem cell proliferation, the niche factor(s) responsible for quiescence induction remain unclear. Here we report an in vivo imaging-based screen which identifies Oncostatin M (OSM), a member of the interleukin-6 family of...
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