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Article

Ex Vivo Expansion and In Vivo Self-Renewal of Human Muscle Stem Cells

4 Sept 2015

Abstract excerpt

Adult skeletal muscle stem cells, or satellite cells (SCs), regenerate functional muscle following transplantation into injured or diseased tissue. To gain insight into human SC (huSC) biology, we analyzed transcriptome dynamics by RNA sequencing of prospectively isolated quiescent and activated huSCs. This analysis indicated that huSCs differentiate and lose proliferative potential when maintained in...

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PMID: 26344908
DOI: 10.1016/j.stemcr.2015.08.004

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