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Hepatitis B Virus Core Protein Dephosphorylation Occurs during Pregenomic RNA Encapsidation

17 Apr 2018

Abstract excerpt

ABSTRACT Hepatitis B virus (HBV) core protein consists of an N-terminal assembly domain and a C-terminal domain (CTD) with seven conserved serines or threonines that are dynamically phosphorylated/dephosphorylated during the viral replication cycle. Sulfamoylbenzamide derivatives are small molecular core protein allosteric modulators (CpAMs) that bind to the heteroaryldihydropyrimidine (HAP) pocket between the...

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PMID: 29669831
DOI: 10.1128/jvi.02139-17

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