Chronic lithium treatment induces novel patterns of pendrin localization and expression.

doi:10.1152/ajprenal.00065.2018

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Article

Chronic lithium treatment induces novel patterns of pendrin localization and expression.

American journal of physiology. Renal physiology - 1 Aug 2018

Himmel Nathaniel J, Wang Yirong, Rodriguez Daniel A, Sun Michael A, Blount Mitsi A

Abstract excerpt

Prolonged lithium treatment is associated with various renal side effects and is known to induce inner medullary collecting duct (IMCD) remodeling. In animals treated with lithium, the fraction of intercalated cells (ICs), which are responsible for acid-base homeostasis, increases compared with renal principal cells (PCs). To investigate the intricacies of lithium-induced IMCD remodeling, male Sprague-Dawley rats...

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Identifiers

PMID: 29667915
DOI: 10.1152/ajprenal.00065.2018
PMCID: PMC6139525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.