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Article

Functional characterization of pendrin in a polarized cell system. Evidence for pendrin-mediated apical iodide efflux.

The Journal of biological chemistry - 26 Mar 2004

Gillam Mary P, Sidhaye Aniket R, Lee Eun Jig, Rutishauser Jonas, Stephan Catherine Waeber, Kopp Peter

Abstract excerpt

Pendred's syndrome is an autosomal recessive disorder characterized by sensorineural deafness, goiter, and impaired iodide organification. It is caused by mutations in the PDS/SLC26A4 gene that encodes pendrin. Functionally, pendrin is a transporter of chloride and iodide in Xenopus oocytes and h...

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Identifiers

PMID: 14715652
DOI: 10.1074/jbc.M313648200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14715652-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Functional characterization of pendrin in a polarized cell system. Evidence for pendrin-mediated apical iodide efflux.PMID 14715652Read ↗

Controversies concerning the role of pendrin as an apical iodide transporter in thyroid follicular cells.Semantic proximity Read ↗

Genetics and phenomics of Pendred syndrome.Semantic proximity Read ↗

Mutations of the PDS gene, encoding pendrin, are associated with protein mislocalization and loss of iodide efflux: implications for thyroid dysfunction in Pendred syndrome.Semantic proximity Read ↗

Mutations of the PDS Gene, Encoding Pendrin, Are Associated with Protein Mislocalization and Loss of Iodide Efflux: Implications for Thyroid Dysfunction in Pendred SyndromeSemantic proximity Read ↗

Pendrin, the Protein Encoded by the Pendred Syndrome Gene (PDS), Is an Apical Porter of Iodide in the Thyroid and Is Regulated by Thyroglobulin in FRTL-5 CellsSemantic proximity Read ↗

Clinical and molecular characteristics of Pendred syndrome.Semantic proximity Read ↗

Analysis of cellular localization and function of carboxy-terminal mutants of pendrin.Semantic proximity Read ↗

Pendred syndrome.Semantic proximity Read ↗

The role of pendrin in iodide regulation.Semantic proximity Read ↗

Pendred syndrome.Semantic proximity Read ↗

[Pendrin: physiology, molecular biology and clinical importance].Semantic proximity Read ↗

Mutations in the Pendred Syndrome (PDS/SLC26A) Gene: An Increasingly Complex Phenotypic Spectrum From Goiter to Thyroid HypoplasiaSemantic proximity Read ↗

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