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Article

Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records.

Translational psychiatry - 18 Apr 2018

Chen Chia-Yen, Lee Phil H, Castro Victor M, Minnier Jessica, Charney Alexander W, Stahl Eli A, Ruderfer Douglas M, Murphy Shawn N, Gainer Vivian, Cai Tianxi, Jones Ian, Pato Carlos N, Pato Michele T, Landén Mikael, Sklar Pamela, Perlis Roy H, Smoller Jordan W

Abstract excerpt

Bipolar disorder (BD) is a heritable mood disorder characterized by episodes of mania and depression. Although genomewide association studies (GWAS) have successfully identified genetic loci contributing to BD risk, sample size has become a rate-limiting obstacle to genetic discovery. Electronic health records (EHRs) represent a vast but relatively untapped resource for high-throughput phenotyping. As part of the...

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PMID: 29666432
DOI: 10.1038/s41398-018-0133-7
PMCID: PMC5904248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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