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Article

Genetic variability of the U5 and downstream sequence of major HIV-1 subtypes and circulating recombinant forms.

Scientific reports - 6 Aug 2020

Mbondji-Wonje Christelle, Dong Ming, Zhao Jiangqin, Wang Xue, Nanfack Aubin, Ragupathy Viswanath, Sanchez Ana M, Denny Thomas N, Hewlett Indira

Abstract excerpt

The critical role of the regulatory elements at the 5' end of the HIV-1 genome in controlling the life cycle of HIV-1 indicates that this region significantly influences virus fitness and its biological properties. In this study, we performed a detailed characterization of strain-specific variability of sequences from the U5 to upstream of the gag gene start codon of diverse HIV-1 strains by using next-generation...

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Share to 5' Untranslated Regions
Share to Binding Sites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

Share to High-Throughput Nucleotide Sequencing

Share to Recombination, Genetic

Share to RNA, Viral

Share to Species Specificity

Source

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Identifiers

PMID: 32764600
DOI: 10.1038/s41598-020-70083-1
PMCID: PMC7411029

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