MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer.

doi:10.1158/0008-5472.CAN-22-0770

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Article

MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer.

Cancer research - 2 Nov 2022

Yoshida Ryohei, Saigi Maria, Tani Tetsuo, Springer Benjamin F, Shibata Hirofumi, Kitajima Shunsuke, Mahadevan Navin R, Campisi Marco, Kim William, Kobayashi Yoshihisa, Thai Tran C, Haratani Koji, Yamamoto Yurie, Sundararaman Shriram K, Knelson Erik H, Vajdi Amir, Canadas Israel, Uppaluri Ravindra, Paweletz Cloud P, Miret Juan J, Lizotte Patrick H, Gokhale Prafulla C, Jänne Pasi A, Barbie David A

Abstract excerpt

Immunotherapy has shown limited efficacy in patients with EGFR-mutated lung cancer. Efforts to enhance the immunogenicity of EGFR-mutated lung cancer have been unsuccessful to date. Here, we discover that MET amplification, the most common mechanism of resistance to third-generation EGFR tyrosine kinase inhibitors (TKI), activates tumor cell STING, an emerging determinant of cancer immunogenicity (1). However,...

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PMID: 36066413
DOI: 10.1158/0008-5472.CAN-22-0770
PMCID: PMC9627131

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