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Article

The regulation of CD73 in non-small cell lung cancer.

European journal of cancer (Oxford, England : 1990) - 1 Jul 2022

Han Yumin, Lee Trevor, He Yongfeng, Raman Renuka, Irizarry Adriana, Martin M Laura, Giaccone Giuseppe

Abstract excerpt

BACKGROUND: Lung cancer is the leading cause of global cancer-related mortality. Although immune checkpoint therapy has achieved remarkable results in lung cancer, EGFR-mutant or ALK-positive non-smallcell lung cancer patients show limited benefit. Besides the low tumor mutational burden, PD-L1 expression and CD8+ tumor-infiltrating T cells, upregulation of CD73/adenosine pathway also contributes to the...

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PMID: 35598361
DOI: 10.1016/j.ejca.2022.04.025

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