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Article

The Genetic Polymorphism UGT1A4*3 Is Associated with Low Posaconazole Plasma Concentrations in Hematological Malignancy Patients Receiving the Oral Suspension.

Antimicrobial agents and chemotherapy - 1 Jul 2018

Suh Hyeon Jeong, Yoon Seo Hyun, Yu Kyung-Sang, Cho Joo-Youn, Park Sang-In, Lee Eunyoung, Lee Jeong-Ok, Koh Youngil, Song Kyoung-Ho, Choe Pyoeng Gyun, Kim Eu Suk, Bang Soo-Mee, Kim Hong Bin, Kim Inho, Kim Nam Joong, Song Sang Hoon, Park Wan Beom, Oh Myoung-Don

Abstract excerpt

The metabolism of posaconazole is mediated mainly by uridine 5'-diphospho-glucuronosyltransferase (UGT) enzymes, especially UGT1A4. The aim of this study was to investigate the effects of genetic polymorphisms on the posaconazole plasma concentration (PPC). This prospective study was conducted from September 2014 to August 2016. We enrolled patients with acute myeloid leukemia or myelodysplastic syndrome treated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29661871
DOI: 10.1128/AAC.02230-17
PMCID: PMC6021653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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