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Article

Generation of multidrug resistant human tissues by overexpression of the ABCG2 multidrug transporter in embryonic stem cells.

PloS one - 1 Jan 2018

Erdei Zsuzsa, Schamberger Anita, Török György, Szebényi Kornélia, Várady György, Orbán Tamás I, Homolya László, Sarkadi Balázs, Apáti Ágota

Abstract excerpt

The ABCG2 multidrug transporter provides resistance against various endo- and xenobiotics, and protects the stem cells against toxins and stress conditions. We have shown earlier that a GFP-tagged version of ABCG2 is fully functional and may be used to follow the expression, localization and function of this transporter in living cells. In the present work we have overexpressed GFP-ABCG2, driven by a constitutive...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple

Share to Embryonic Stem Cells

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Source

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Identifiers

PMID: 29649238
DOI: 10.1371/journal.pone.0194925
PMCID: PMC5896897

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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