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Article

The association of NF2 (neurofibromin 2) gene polymorphism and the risk of medulloblastomas.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Jul 2018

Zhao Cailei, Chen Qian, Li Chunde, Yang Jian, Li Cong, Zhou Yangyang, Liao Jianxiang

Abstract excerpt

To explore the relationship between NF2 promoter gene mutation and the risk of medulloblastomas (MBs). We collected tissues from 16 MB patients and 7 age-matched non-MB controls. Gene sequencing, qPCR (real-time quantitative polymerase chain reaction), IHC (immunohistochemistry), and WB (Western blot) were used to analyze the changes in the NF2 gene sequence and expression between patients and controls. We found...

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PMID: 29637450
DOI: 10.1007/s10072-018-3327-0

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