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Article

Tumor necrosis factor-alpha -1031T/C polymorphism is associated with cognitive deficits in chronic schizophrenia patients versus healthy controls.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2018

Xiu Mei Hong, Man Li-Juan, Wang Dong, Du Xiangdong, Yin Guangzhou, Zhang Yingyang, Tan Yun Long, Chen Nan, Chen Song, Teixeira Antonio L, Cassidy Ryan M, Soares Jair C, Zhang Xiang Yang

Abstract excerpt

Recent compelling research has demonstrated a pathophysiologic role for proinflammatory cytokines of microglial origin in decreasing neurocognitive function. Psychiatric diseases are already known to have reduced cognitive function and are also associated with increased inflammation. To elaborate on these data, our study aims to investigate how a particular polymorphism of the tumor necrosis factor gene, TNF-α...

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PMID: 29633506
DOI: 10.1002/ajmg.b.32622

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TNF

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