Article
DNA methylation-based subclassification of psoriasis in the Chinese Han population.
Frontiers of medicine - 1 Dec 2018
Zhou Fusheng, Shen Changbing, Hsu Yi-Hsiang, Gao Jing, Dou Jinfa, Ko Randy, Zheng Xiaodong, Sun Liangdan, Cui Yong, Zhang Xuejun
Abstract excerpt
Psoriasis (Ps) is an inflammatory skin disease caused by genetic and environmental factors. Previous studies on DNA methylation (DNAm) found genetic markers that are closely associated with Ps, and evidence has shown that DNAm mediates genetic risk in Ps. In this study, Consensus Clustering was used to analyze DNAm data, and 114 Ps patients were divided into three subclassifications. Investigation of the clinical...
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