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Article

Modern simulation utilities for genetic analysis.

BMC bioinformatics - 3 May 2021

Ji Sarah S, German Christopher A, Lange Kenneth, Sinsheimer Janet S, Zhou Hua, Zhou Jin, Sobel Eric M

Abstract excerpt

BACKGROUND: Statistical geneticists employ simulation to estimate the power of proposed studies, test new analysis tools, and evaluate properties of causal models. Although there are existing trait simulators, there is ample room for modernization. For example, most phenotype simulators are limited to Gaussian traits or traits transformable to normality, while ignoring qualitative traits and realistic, non-normal...

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Identifiers

PMID: 33941078
DOI: 10.1186/s12859-021-04086-8
PMCID: PMC8091532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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