Activation of the complement system in an osteosarcoma cell line promotes angiogenesis through enhanced production of growth factors

Abstract excerpt

There is increasing evidence that the complement system is activated in various cancer tissues. Besides being involved in innate immunity against pathogens, the complement system also participates in inflammation and the modulation of tumor microenvironment. Recent studies suggest that complement activation promotes tumor progression in various ways. Among some cancer cell lines, we found that human bone...