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Flavivirus internalization is regulated by a size-dependent endocytic pathway

2 Apr 2018

Abstract excerpt

Flaviviruses enter host cells through the process of clathrin-mediated endocytosis, and the spectrum of host factors required for this process are incompletely understood. Here we found that lymphocyte antigen 6 locus E (LY6E) promotes the internalization of multiple flaviviruses, including West Nile virus, Zika virus, and dengue virus. Perhaps surprisingly, LY6E is dispensable for the internalization of the...

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PMID: 29610346
DOI: 10.1073/pnas.1720032115

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