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Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?

2 Apr 2018

Abstract excerpt

Porcine endogenous retroviruses (PERVs) are present in the genome of all pigs, they infect certain human cells and therefore pose a special risk for xenotransplantation using pig cells, tissues and organs. Xenotransplantation is being developed in order to alleviate the reduced availability of human organs. Despite the fact that PERVs are able to infect certain human cells and cells from other species,...

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PMID: 29609635
DOI: 10.1186/s12977-018-0411-8

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