Article
A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses.
PLoS genetics - 1 Apr 2018
Baranski Thomas J, Kraja Aldi T, Fink Jill L, Feitosa Mary, Lenzini Petra A, Borecki Ingrid B, Liu Ching-Ti, Cupples L Adrienne, North Kari E, Province Michael A
Abstract excerpt
Human GWAS of obesity have been successful in identifying loci associated with adiposity, but for the most part, these are non-coding SNPs whose function, or even whose gene of action, is unknown. To help identify the genes on which these human BMI loci may be operating, we conducted a high throughput screen in Drosophila melanogaster. Starting with 78 BMI loci from two recently published GWAS meta-analyses, we...
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