Article

SMAD4 Loss is Associated with Response to Neoadjuvant Chemotherapy with Hydroxychloroquine in Patients with Pancreatic Adenocarcinoma

2020-12-11

Abstract excerpt

<title>Abstract</title> <p>Background <italic>SMAD4</italic>, a tumor suppressor gene, is inactivated or deleted in 60–90% of pancreatic adenocarcinomas (PDA). Loss of SMAD4 allows tumor progression by limiting cell cycle arrest and apoptosis and increasing metastases. SMAD4 deficient PDA cells are resistant to radiotherapy by upregulating autophagy, a cell survival mechanism that counteracts apoptotic mechanis...

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Literature Corpus work: 267d4b79-1996-5598-a5e2-dc0c323ea860
DOI: 10.21203/rs.3.rs-125334/v1

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