Article
Structures of the Mycobacterium tuberculosis GlpX protein (class II fructose-1,6-bisphosphatase): implications for the active oligomeric state, catalytic mechanism and citrate inhibition.
Acta crystallographica. Section D, Structural biology - 1 Apr 2018
Wolf Nina M, Gutka Hiten J, Movahedzadeh Farahnaz, Abad-Zapatero Celerino
Abstract excerpt
The crystal structures of native class II fructose-1,6-bisphosphatase (FBPaseII) from Mycobacterium tuberculosis at 2.6 Å resolution and two active-site protein variants are presented. The variants were complexed with the reaction product fructose 6-phosphate (F6P). The Thr84Ala mutant is inactive, while the Thr84Ser mutant has a lower catalytic activity. The structures reveal the presence of a 222 tetramer,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.