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Article

Transcriptional signature associated with early rheumatoid arthritis and healthy individuals at high risk to develop the disease

27 Mar 2018

Abstract excerpt

BACKGROUND: Little is known regarding the mechanisms underlying the loss of tolerance in the early and preclinical stages of autoimmune diseases. The aim of this work was to identify the transcriptional profile and signaling pathways associated to non-treated early rheumatoid arthritis (RA) and subjects at high risk. Several biomarker candidates for early RA are proposed. METHODS: Whole blood total RNA was...

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PMID: 29584756
DOI: 10.1371/journal.pone.0194205

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