Article
Simultaneous detection of ABL1 mutation and IKZF1 deletion in Philadelphia chromosome-positive acute lymphoblastic leukemia using a customized target enrichment system panel.
International journal of laboratory hematology - 1 Aug 2018
Aoe M, Ishida H, Matsubara T, Karakawa S, Kawaguchi H, Fujiwara K, Kanamitsu K, Washio K, Okada K, Shibakura M, Shimada A
Abstract excerpt
INTRODUCTION: Recent clinical outcomes of pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) vastly improved owing to tyrosine kinase inhibitor (TKI). However, the genetic status would be different in each case with ABL1 gene mutation or copy number variants (CNVs) such as IKZF1 deletion. In particular, the TKI resistant clone with ABL1 kinase mutation remains problematic. The...
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