Article
Identification of Indonesian clade 2.1 highly pathogenic influenza A(H5N1) viruses with N294S and S246N neuraminidase substitutions which further reduce oseltamivir susceptibility.
Antiviral research - 1 May 2018
McKimm-Breschkin Jennifer L, Barrett Susan, Wong Frank Y K, Pudjiatmoko, Azhar Muhammad, Selleck Paul, Davies Kelly R, Hartaningsih Nining, McGrane James
Abstract excerpt
We have tested the in vitro susceptibility to the neuraminidase (NA) inhibitors of 96 highly pathogenic clade 2.1 A(H5N1) viruses from Indonesia, isolated between 2008 and 2011. HPAI virus samples obtained through the Influenza Virus Monitoring (IVM) surveillance program in Indonesia were tested for susceptibility to oseltamivir and zanamivir. The NAs of four viruses were identified as extreme outliers to...
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