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Regression of Melanoma in a Murine Model by RLIP76 Depletion

15 Feb 2006

Abstract excerpt

RLIP76/RALBP1 is a stress-responsive membrane protein implicated in the regulation of multiple cellular signaling pathways. It represents the predominant glutathione-conjugate transporter in cells, and our previous studies have shown that its inhibition by antibodies or depletion by short interfering RNA (siRNA) causes apoptosis in a number of cancer cell types. The present studies were done to explore the...

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PMID: 16489041
DOI: 10.1158/0008-5472.can-05-3534

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