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Discovery of a Pederin Family Compound in a Nonsymbiotic Bloom-Forming Cyanobacterium

23 Mar 2018

Abstract excerpt

The pederin family includes a number of bioactive compounds isolated from symbiotic organisms of diverse evolutionary origin. Pederin is linked to beetle-induced dermatitis in humans, and pederin family members possess potent antitumor activity caused by selective inhibition of the eukaryotic ribosome. Their biosynthesis is accomplished by a polyketide/nonribosomal peptide synthetase machinery employing an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29570981
DOI: 10.1021/acschembio.7b01048

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