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Article

Considerations for biomarker-targeted intervention strategies for tuberculosis disease prevention.

Tuberculosis (Edinburgh, Scotland) - 1 Mar 2018

Fiore-Gartland Andrew, Carpp Lindsay N, Naidoo Kogieleum, Thompson Ethan, Zak Daniel E, Self Steve, Churchyard Gavin, Walzl Gerhard, Penn-Nicholson Adam, Scriba Thomas J, Hatherill Mark

Abstract excerpt

Current diagnostic tests for Mycobacterium tuberculosis (MTB) infection have low prognostic specificity for identifying individuals who will develop tuberculosis (TB) disease, making mass preventive therapy strategies targeting all MTB-infected individuals impractical in high-burden TB countries. Here we discuss general considerations for a risk-targeted test-and-treat strategy based on a highly specific...

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Identifiers

PMID: 29559122
DOI: 10.1016/j.tube.2017.11.009
PMCID: PMC5884308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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