Article
Phospholipid flippases and Sfk1p, a novel regulator of phospholipid asymmetry, contribute to low permeability of the plasma membrane.
Molecular biology of the cell - 15 May 2018
Mioka Tetsuo, Fujimura-Kamada Konomi, Mizugaki Nahiro, Kishimoto Takuma, Sano Takamitsu, Nunome Hitoshi, Williams David E, Andersen Raymond J, Tanaka Kazuma
Abstract excerpt
Phospholipid flippase (type 4 P-type ATPase) plays a major role in the generation of phospholipid asymmetry in eukaryotic cell membranes. Loss of Lem3p-Dnf1/2p flippases leads to the exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the cell surface in yeast, resulting in sensitivity to PS- or PE-binding peptides. We isolated Sfk1p, a conserved membrane protein in the TMEM150/FRAG1/DRAM...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.