Article
CTLA-4 Polymorphisms in Patients with IgA Nephropathy Correlate with Proteinuria.
Kidney & blood pressure research - 1 Jan 2018
Jacob Marius, Ohl Kim, Goodarzi Tannaz, Harendza Sigrid, Eggermann Thomas, Fitzner Christina, Hilgers Ralf-Dieter, Bolte Anna, Floege Jürgen, Rauen Thomas, Tenbrock Klaus
Abstract excerpt
BACKGROUND/AIMS: IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis and still constitutes one of the most important causes of end-stage renal disease. Abnormal T cell responses may play a role in IgAN pathogenesis. Co-stimulatory molecules such as cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) are important for naive T cells to initiate and terminate immune responses. Single...
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