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Article

Single nucleotide polymorphisms in the dual specificity phosphatase genes and risk of necrotizing enterocolitis in premature infant.

Journal of neonatal-perinatal medicine - 1 Jan 2020

Talavera M M, Jin Y, Zmuda E J, Frick J, Liu Y, McBride K L, Nelin L D, Trittmann J K

Abstract excerpt

BACKGROUND: Differences in the susceptibility of preterm infants to develop necrotizing enterocolitis (NEC) implicate potential genetic differences in response to the inflammatory stimuli leading to NEC. Dual specificity phosphatases (DUSPs) are a key suppressor pathway of the mitogen-activated protein kinase (MAPK) pro-inflammatory signaling pathway. We hypothesized that inherited single nucleotide polymorphisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31985475
DOI: 10.3233/NPM-190302
PMCID: PMC8394167

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