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Herpesviruses possess conserved proteins for interaction with Nedd4 family ubiquitin E3 ligases

7 Mar 2018

Abstract excerpt

Nedd4 is a family of ubiquitin E3 ligases that regulate numerous cellular processes. In this report, we showed that alpha- and beta-herpesviruses have membrane proteins that regulate the function of the Nedd4 family members. Although the homology search score was quite low, UL56 of herpes simplex virus type 1 and 2, ORF0 of varicella-zoster virus, UL42 of human cytomegalovirus, and U24 of human herpesvirus 6A,...

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PMID: 29535361
DOI: 10.1038/s41598-018-22682-2

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