Article
Hyperacute Monocyte Gene Response Patterns Are Associated With Lower Extremity Vein Bypass Graft Failure.
Circulation. Genomic and precision medicine - 1 Mar 2018
Rehfuss Jonathan P, DeSart Kenneth M, Rozowsky Jared M, O'Malley Kerri A, Moldawer Lyle L, Baker Henry V, Wang Yaqun, Wu Rongling, Nelson Peter R, Berceli Scott A
Abstract excerpt
BACKGROUND: Despite being the definitive treatment for lower extremity peripheral arterial disease, vein bypass grafts fail in half of all cases. Early repair mechanisms after implantation, governed largely by the immune environment, contribute significantly to long-term outcomes. The current study investigates the early response patterns of circulating monocytes as a determinant of graft outcome. METHODS: In 48...
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