Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of trophoblastic epigenetic reprogrammation in benign tumor cells on malignant progression: A molecular hypothesis.

Medical hypotheses - 1 Apr 2018

Doello Kevin

Abstract excerpt

Cancer tissues and placental ones share many properties such as invasiveness, metastasis and local immunosuppressive effects. The goal of the present article is to hypothesize a theory about cancer origin that links placental and cancerous tissues at molecular level. This hypothesis explain that cancer origin could be due to low hypoxic conditions in the peripheral zones of benign tumors which might up-regulate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neoplasm Metastasis
Share to Diagnosis, Differential
Share to Immunosuppressive Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor II

Share to Models, Theoretical

Share to Neoplasm Invasiveness

Share to Placenta

Share to Trophoblasts

Source

Identifiers

PMID: 29523298
DOI: 10.1016/j.mehy.2018.02.019

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of trophoblastic epigenetic reprogrammation in benign tumor cells on malignant progression: A molecular hypothesis.PMID 29523298Read ↗

Trophoblastic-like transdifferentiation: A key to oncogenesis.Semantic proximity Read ↗

A unifying concept of trophoblastic differentiation and malignancy defined by biomarker expressionSemantic proximity Read ↗

Cancer and Pregnancy Share Similar Mechanisms of Immunological EscapeSemantic proximity Read ↗

Potential role of epigenetic mechanisms in regulation of trophoblast differentiation, migration, and invasion in the human placentaSemantic proximity Read ↗

Shifting perspectives from “oncogenic” to oncofetal proteins; how these factors drive placental developmentSemantic proximity Read ↗

[Biology of the trophoblastic tissue and placental tumors].Semantic proximity Read ↗

Trophoblast 'pseudo-tumorigenesis': Significance and contributory factorsSemantic proximity Read ↗

Molecular Basis of Hydatidiform Moles – A Systematic ReviewSemantic proximity Read ↗

Molecular Genetic Analysis of Placental Site Trophoblastic Tumors and Epithelioid Trophoblastic Tumors Confirms Their Trophoblastic OriginSemantic proximity Read ↗

Insights into the Pathogenesis of Preeclampsia Based on the Features of Placentation and TumorigenesisSemantic proximity Read ↗

Placental pseudo-malignancy from a DNA methylation perspective: unanswered questions and future directionsSemantic proximity Read ↗

Regulation of invasive growth: similar epigenetic mechanisms underpin tumour progression and implantation in human pregnancySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.