Trophoblastic-like transdifferentiation: A key to oncogenesis.

doi:10.1016/j.critrevonc.2016.01.019

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Article

Trophoblastic-like transdifferentiation: A key to oncogenesis.

Critical reviews in oncology/hematology - 1 May 2016

Piechowski Jean

Abstract excerpt

The epigenetic plasticity of cancer stem-like cells allows them to reprogram multifaceted properties. Being determined by an oncogene driving force, the reprogrammed properties are suitable for extensive, non-homeostatic clone expansion rather than controlled tissue generation. They belong to physiological phenotypes, under strict control in normal cells but illicitly expressed in malignant cells. Comparing the...

Topics

Cell Transdifferentiation
Cell Transformation, Neoplastic
Humans
Phenotype
Trophoblasts

Source

Open in PubMed

Identifiers

PMID: 26948538
DOI: 10.1016/j.critrevonc.2016.01.019

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