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Cancer and Pregnancy Share Similar Mechanisms of Immunological Escape

1 Jan 2006

Abstract excerpt

BACKGROUND: Despite the fact that trophoblasts and cancer are both immunogenic, they are able to escape from host immunosurveillance, and the precise mechanisms involved in this process are surprisingly similar in both situations. METHODS: A literature review of studies on immunological changes occurring during normal pregnancy and cancer was performed. RESULTS: Loss or downregulation of classical HLA antigens as...

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PMID: 16612052
DOI: 10.1159/000092537

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