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Article

A Bone-Protective Role for IFN-γ? Evidence from Genetic Association and Osteoblast Functional Assays in Postmenopausal Osteoporosis.

International journal of molecular sciences - 19 Jun 2026

de Lima Camilla Albertina Dantas, Souza Anna Paula Oliveira, Seabra Maria Aparecida Barreto Lopes, Guaraná Werbson Lima, Oliveira Bianca Maria Ribeiro de, Crovella Sergio, Barbosa Alexandre Domingues, de Azevêdo Silva Jaqueline, Sandrin-Garcia Paula

Abstract excerpt

Osteoporosis (OP) is a complex disease in which several immune-related genes have been identified as contributing to susceptibility and disease progression. Despite efforts to achieve functional validation, many of these genes, such as interferon-gamma (IFNG), remain the subject of unresolved mechanisms. The present study aimed to examine whether the IFNG -1616 (G>A, rs2069705) polymorphism was associated with...

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Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Association Studies

Interferon-gamma

Osteoporosis, Postmenopausal

Polymorphism, Single Nucleotide

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Open in PubMed Open full text

Identifiers

PMID: 42353262
DOI: 10.3390/ijms27125548
PMCID: PMC13299862

Genes

IFNG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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