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Article

Identification of H209 as Essential for pH 8-Triggered Receptor-Independent Syncytium Formation by S Protein of Mouse Hepatitis Virus A59.

Journal of virology - 1 Jun 2018

Li Pei, Shan Yiwei, Zheng Wangliang, Ou Xiuyuan, Mi Dan, Mu Zhixia, Holmes Kathryn V, Qian Zhaohui

Abstract excerpt

The spike glycoprotein (S) of murine coronavirus mouse hepatitis virus (MHV) strain A59 uses murine carcinoembryonic antigen-related cell adhesion molecule 1a as its receptor for cell entry, but S protein can also be triggered in the absence of receptor by pH 8.0 alone at 37°C. The mechanism by which conformational changes of this S glycoprotein can be triggered by pH 8.0 has not yet been determined. Here, we...

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Identifiers

PMID: 29514915
DOI: 10.1128/JVI.00209-18
PMCID: PMC5952161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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