Article
Multiplex genomewide association analysis of breast milk fatty acid composition extends the phenotypic association and potential selection of FADS1 variants to arachidonic acid, a critical infant micronutrient.
Journal of medical genetics - 1 Jul 2018
Mychaleckyj Josyf C, Nayak Uma, Colgate E Ross, Zhang Dadong, Carstensen Tommy, Ahmed Shahnawaz, Ahmed Tahmeed, Mentzer Alexander J, Alam Masud, Kirkpatrick Beth D, Haque Rashidul, Faruque Abu Syed Golam, Petri William A
Abstract excerpt
BACKGROUND: Breast milk is the sole nutrition source during exclusive breastfeeding, and polyunsaturated fatty acids (FAs) are critical micronutrients in infant physical and cognitive development. There has been no prior genomewide association study of breast milk, hence our objective was to test for genetic association with breast milk FA composition. METHODS: We measured the fractional composition of 26...
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