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Article

FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk.

The American journal of clinical nutrition - 1 May 2010

Moltó-Puigmartí Carolina, Plat Jogchum, Mensink Ronald P, Müller André, Jansen Eugène, Zeegers Maurice P, Thijs Carel

Abstract excerpt

BACKGROUND: The genes encoding Delta(5)- and Delta(6)-desaturases (FADS1 FADS2 gene cluster) were reported to be associated with n-3 (omega-3) and n-6 (omega-6) fatty acid proportions in human plasma, tissues, and milk. Docosahexaenoic acid (DHA) can be supplied especially by dietary fish or fish oil and synthesized from alpha-linolenic acid through a pathway involving these desaturases. OBJECTIVE: We evaluated...

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Source

Identifiers

PMID: 20335541
DOI: 10.3945/ajcn.2009.28789

Genes

FADS1
FADS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk.PMID 20335541Read ↗

Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation.Semantic proximity Read ↗

Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children.Semantic proximity Read ↗

Maternal but not fetal FADS gene variants modify the association between maternal long-chain PUFA intake in pregnancy and birth weight.Semantic proximity Read ↗

FADS Genetic Variants in Taiwanese Modify Association of DHA Intake and Its Proportions in Human Milk.Semantic proximity Read ↗

FADS genotype and diet are important determinants of DHA status: a cross-sectional study in Danish infants.Semantic proximity Read ↗

Can polymorphisms in the fatty acid desaturase (FADS) gene cluster alter the effects of fish oil supplementation on plasma and erythrocyte fatty acid profiles? An exploratory study.Semantic proximity Read ↗

Influence of fatty acid desaturase (FADS) genotype on maternal and child polyunsaturated fatty acids (PUFA) status and child health outcomes: a systematic review.Semantic proximity Read ↗

Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study.Semantic proximity Read ↗

Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplementSemantic proximity Read ↗

Association of polyunsaturated fatty acids in breast milk with fatty acid desaturase gene polymorphisms among Chinese lactating mothers.Semantic proximity Read ↗

Genetic variants in the FADS gene cluster are associated with arachidonic acid concentrations of human breast milk at 1.5 and 6 mo postpartum and influence the course of milk dodecanoic, tetracosenoic, and trans-9-octadecenoic acid concentrations over the duration of lactation.Semantic proximity Read ↗

Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study.Semantic proximity Read ↗

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