Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study.

doi:10.1016/j.plefa.2015.08.004

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Article

Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study.

Prostaglandins, leukotrienes, and essential fatty acids - 1 Dec 2015

Yeates Alison J, Love Tanzy M, Engström Karin, Mulhern Maria S, McSorley Emeir M, Grzesik Katherine, Alhamdow Ayman, Wahlberg Karin, Thurston Sally W, Davidson Philip W, van Wijngaarden Edwin, Watson Gene E, Shamlaye Conrad F, Myers G J, Strain J J, Broberg Karin

Abstract excerpt

Long-chain n-6 and n-3 PUFA (LC-PUFA), arachidonic acid (AA) (20:4n-6) and DHA (22:6n-3), are critical for optimal brain development. These fatty acids can be consumed directly from the diet, or synthesized endogenously from precursor PUFA by Δ-5 (encoded by FADS1) and Δ-6 desaturases (encoded by FADS2). The aim of this study was to determine the potential importance of maternal genetic variability in FADS1 and...

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Identifiers

PMID: 26474818
DOI: 10.1016/j.plefa.2015.08.004
PMCID: PMC4746501

Genes

FADS1
FADS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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