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Article

Post-translational modification of OCT4 in breast cancer tumorigenesis

6 Mar 2018

Abstract excerpt

Recurrence and drug resistance of breast cancer are still the main reasons for breast cancer-associated deaths. Cancer stem cell (CSC) model has been proposed as a hypothesis for the lethality of breast cancer. Molecular mechanisms underlying CSC maintenance are still unclear. In this study, we generated mammospheres derived from breast cancer MDA-MB231 cells and MCF7 cells to enrich CSCs and performed DNA...

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PMID: 29511337
DOI: 10.1038/s41418-018-0079-6

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