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Article

VEGF and GLUT1 are highly heritable, inversely correlated and affected by dietary fat intake: Consequences for cognitive function in humans.

Molecular metabolism - 1 May 2018

Schüler Rita, Seebeck Nicole, Osterhoff Martin A, Witte Veronica, Flöel Agnes, Busjahn Andreas, Jais Alexander, Brüning Jens C, Frahnow Turid, Kabisch Stefan, Pivovarova Olga, Hornemann Silke, Kruse Michael, Pfeiffer Andreas F H

Abstract excerpt

OBJECTIVE: Reduction of brain glucose transporter GLUT1 results in severe neurological dysfunction. VEGF is required to restore and maintain brain glucose uptake across the blood brain barrier via GLUT1, which was shown to be acutely diminished in response to a high fat diet (HFD) in mice. The genetic and HFD-related regulation and association of VEGF and GLUT1 (SLC2A1) in humans was investigated in the...

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Identifiers

PMID: 29506909
DOI: 10.1016/j.molmet.2018.02.004
PMCID: PMC6001408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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