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Article

Glyoxalase 1 sustains the metastatic phenotype of prostate cancer cells via EMT control.

Journal of cellular and molecular medicine - 1 May 2018

Antognelli Cinzia, Cecchetti Rodolfo, Riuzzi Francesca, Peirce Matthew J, Talesa Vincenzo N

Abstract excerpt

Metastasis is the primary cause of death in prostate cancer (PCa) patients. Effective therapeutic intervention in metastatic PCa is undermined by our poor understanding of its molecular aetiology. Defining the mechanisms underlying PCa metastasis may lead to insights into how to decrease morbidity and mortality in this disease. Glyoxalase 1 (Glo1) is the detoxification enzyme of methylglyoxal (MG), a potent...

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Identifiers

PMID: 29504694
DOI: 10.1111/jcmm.13581
PMCID: PMC5908125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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