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Article

Relevance of CYP3A420, UGT1A137 and UGT1A1*28 variants in irinotecan-induced severe toxicity.

British journal of clinical pharmacology - 1 Jun 2018

Riera Pau, Salazar Juliana, Virgili Anna C, Tobeña María, Sebio Ana, Gallano Pía, Barnadas Agustí, Páez David

Abstract excerpt

Severe irinotecan-induced toxicity is associated with UGT1A1 polymorphisms. However, some patients develop side-effects despite harbouring a normal UGT1A1 genotype. As CYP3A4 is also an irinotecan-metabolizing enzyme, our study aimed to elucidate the influence of the CYP3A4*20 loss-of-function allele in the toxicity profile of these patients. Three-hundred and eight metastatic colorectal cancer patients treated...

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Identifiers

PMID: 29504153
DOI: 10.1111/bcp.13574
PMCID: PMC5980573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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