Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions.

doi:10.1016/j.ymthe.2018.01.011

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Article

Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions.

Molecular therapy : the journal of the American Society of Gene Therapy - 4 Apr 2018

Jin Hong, Li Daniel Y, Chernogubova Ekaterina, Sun Changyan, Busch Albert, Eken Suzanne M, Saliba-Gustafsson Peter, Winter Hanna, Winski Greg, Raaz Uwe, Schellinger Isabel N, Simon Nancy, Hegenloh Renate, Matic Ljubica Perisic, Jagodic Maja, Ehrenborg Ewa, Pelisek Jaroslav, Eckstein Hans-Henning, Hedin Ulf, Backlund Alexandra, Maegdefessel Lars

Abstract excerpt

miRNAs are potential regulators of carotid artery stenosis and concordant vulnerable atherosclerotic plaques. Hence, we analyzed miRNA expression in laser captured micro-dissected fibrous caps of either ruptured or stable plaques (n = 10 each), discovering that miR-21 was significantly downregulated in unstable lesions. To functionally evaluate miR-21 in plaque vulnerability, miR-21 and miR-21/apolipoprotein-E...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29503197
DOI: 10.1016/j.ymthe.2018.01.011
PMCID: PMC6080193

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