Article
The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications.
Mediators of inflammation - 1 Jan 2017
Alisi Anna, Carpino Guido, Oliveira Felipe L, Panera Nadia, Nobili Valerio, Gaudio Eugenio
Abstract excerpt
The obese phenotype is characterized by a state of chronic low-grade systemic inflammation that contributes to the development of comorbidities, including nonalcoholic fatty liver disease (NAFLD). In fact, NAFLD is often associated with adipocyte enlargement and consequent macrophage recruitment and inflammation. Macrophage polarization is often associated with the proinflammatory state in adipose tissue. In...
Topics
- Adipocytes
- Adipokines
- Adipose Tissue
- Animals
- Fibrosis
- Humans
- Inflammation
- Inflammation Mediators
- Liver
- Macrophages
- Mice
- Non-alcoholic Fatty Liver Disease